Assay Detail
Functional
CHEMBL884010
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxicity of compound against human A549 (non small cell lung) cancer cell line after 72 hr of drug exposure
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Tumor-specific novel taxoid-monoclonal antibody conjugates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 9.03 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL126678 | — | — | 1 | 10.00 |
| CHEMBL153231 | — | — | 1 | 9.10 |
| CHEMBL434130 | — | — | 1 | 9.10 |
| CHEMBL407313 | — | — | 1 | 9.05 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.00 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 2 | 8.52 |
| CHEMBL427593 | — | — | 1 | - |
| CHEMBL409070 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL126678 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL153231 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL434130 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL407313 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL427593 | — | IC50 | > | 3.0 | nM | - |
| CHEMBL409070 | — | IC50 | > | 3.0 | nM | - |