Assay Detail
Functional
CHEMBL884014
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Chemosensitivity against DT-diaphorase rich A549 cell lines
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Bioreductive activation of a series of indolequinones by human DT-diaphorase: structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.22 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74816 | — | — | 1 | 7.48 |
| CHEMBL73822 | APAZIQUONE | 3.0 | 1 | 7.23 |
| CHEMBL308775 | — | — | 1 | 7.16 |
| CHEMBL307665 | — | — | 1 | 6.75 |
| CHEMBL341425 | — | — | 1 | 6.55 |
| CHEMBL329024 | — | — | 1 | 6.30 |
| CHEMBL328535 | — | — | 1 | 6.14 |
| CHEMBL130223 | — | — | 1 | 6.13 |
| CHEMBL338716 | — | — | 1 | 6.10 |
| CHEMBL306559 | — | — | 1 | 6.10 |
| CHEMBL328916 | — | — | 1 | 5.99 |
| CHEMBL77393 | — | — | 1 | 5.87 |
| CHEMBL130409 | — | — | 1 | 5.74 |
| CHEMBL307888 | — | — | 1 | 5.68 |
| CHEMBL94033 | — | — | 1 | 5.45 |
| CHEMBL112472 | — | — | 1 | 4.83 |
| CHEMBL335032 | — | — | 1 | - |
| CHEMBL73067 | — | — | 1 | - |
| CHEMBL133323 | — | — | 1 | - |
| CHEMBL93641 | — | — | 1 | - |
| CHEMBL133390 | — | — | 1 | - |
| CHEMBL131446 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74816 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL73822 | APAZIQUONE | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL308775 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL307665 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL341425 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL329024 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL328535 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL130223 | — | IC50 | = | 741.0 | nM | 6.13 |
| CHEMBL338716 | — | IC50 | = | 787.0 | nM | 6.10 |
| CHEMBL306559 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL328916 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL77393 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL130409 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL307888 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL94033 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL112472 | — | IC50 | = | 14770.0 | nM | 4.83 |
| CHEMBL335032 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL73067 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL133323 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL93641 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL133390 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL131446 | — | IC50 | > | 40000.0 | nM | - |