Assay Detail
Binding
CHEMBL884081
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Effective concentration against RAR-alpha receptor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Conformational effects on retinoid receptor selectivity. 1. Effect of 9-double bond geometry on retinoid X receptor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.66 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39344 | — | — | 1 | 7.57 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 7.57 |
| CHEMBL285179 | — | — | 1 | 7.43 |
| CHEMBL73321 | — | — | 1 | 7.35 |
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 7.35 |
| CHEMBL275311 | — | — | 1 | 7.07 |
| CHEMBL36718 | — | — | 1 | 6.26 |
| CHEMBL86663 | — | — | 1 | 6.00 |
| CHEMBL87147 | — | — | 1 | 5.68 |
| CHEMBL415449 | — | — | 1 | 5.64 |
| CHEMBL26129 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39344 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL38 | TRETINOIN | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL285179 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL73321 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL705 | ALITRETINOIN | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL275311 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL36718 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL86663 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL87147 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL415449 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL26129 | — | EC50 | = | 5000.0 | nM | 5.30 |