Assay Detail
Functional
CHEMBL884107
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Antineoplastic activity against A-549 (human lung carcinoma) cell line.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Selective cytotoxic cyclolignans
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.22 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.92 |
| CHEMBL432749 | — | — | 1 | 7.24 |
| CHEMBL309880 | PODOPHYLLIC ALDEHYDE | — | 1 | 6.92 |
| CHEMBL83373 | — | — | 1 | 6.72 |
| CHEMBL79247 | — | — | 1 | 6.68 |
| CHEMBL311092 | — | — | 1 | 6.66 |
| CHEMBL313476 | — | — | 1 | 6.66 |
| CHEMBL79440 | — | — | 1 | 6.60 |
| CHEMBL313037 | — | — | 1 | 6.24 |
| CHEMBL309540 | — | — | 1 | 6.01 |
| CHEMBL310068 | — | — | 1 | 5.99 |
| CHEMBL83213 | — | — | 1 | 5.96 |
| CHEMBL79846 | — | — | 1 | 5.64 |
| CHEMBL80079 | — | — | 1 | 5.63 |
| CHEMBL310329 | — | — | 1 | 5.25 |
| CHEMBL82303 | PICROPODOPHYLLONE | — | 1 | 4.92 |
| CHEMBL311894 | — | — | 1 | 4.66 |
| CHEMBL63970 | DESOXYPODOPHYLLOTOXIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL432749 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL309880 | PODOPHYLLIC ALDEHYDE | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL83373 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL79247 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL311092 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL313476 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL79440 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL313037 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL309540 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL310068 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL83213 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL79846 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL80079 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL310329 | — | IC50 | = | 5630.0 | nM | 5.25 |
| CHEMBL82303 | PICROPODOPHYLLONE | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL311894 | — | IC50 | = | 21880.0 | nM | 4.66 |
| CHEMBL63970 | DESOXYPODOPHYLLOTOXIN | IC50 | < | 6.0 | nM | - |