Assay Detail
Functional
CHEMBL884131
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration to inhibit growth of C2H prostate cancer cell line by using MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | TRAMP-C2H |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.65 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1637 | GEMCITABINE HYDROCHLORIDE | 4.0 | 1 | 8.33 |
| CHEMBL3038218 | — | — | 1 | 8.04 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.52 |
| CHEMBL3038219 | — | — | 1 | 7.44 |
| CHEMBL3038220 | — | — | 1 | 6.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1637 | GEMCITABINE HYDROCHLORIDE | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL3038218 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 30.3 | nM | 7.52 |
| CHEMBL3038219 | — | IC50 | = | 36.1 | nM | 7.44 |
| CHEMBL3038220 | — | IC50 | = | 116.0 | nM | 6.94 |