Assay Detail
Binding
CHEMBL884132
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Inhibition of Pseudomonas aeruginosa 18SH Beta-lactamase.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Beta-lactamase (CHEMBL5031) ↗| Type | SINGLE PROTEIN |
| Organism | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) |
Publication
Structure-based design of beta-lactamase inhibitors. 1. Synthesis and evaluation of bridged monobactams.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.62 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338157 | — | — | 1 | 7.62 |
| CHEMBL338933 | — | — | 1 | 7.60 |
| CHEMBL2079714 | — | — | 1 | 7.57 |
| CHEMBL130187 | — | — | 1 | 7.32 |
| CHEMBL341484 | — | — | 1 | 7.26 |
| CHEMBL130854 | — | — | 1 | 7.05 |
| CHEMBL340937 | — | — | 1 | 6.96 |
| CHEMBL338351 | — | — | 1 | 6.81 |
| CHEMBL341496 | — | — | 1 | 6.70 |
| CHEMBL340423 | — | — | 1 | 6.70 |
| CHEMBL339600 | — | — | 1 | 6.66 |
| CHEMBL340351 | — | — | 1 | 6.42 |
| CHEMBL129690 | — | — | 1 | 6.38 |
| CHEMBL129226 | — | — | 1 | 6.21 |
| CHEMBL340707 | — | — | 1 | 6.21 |
| CHEMBL129651 | — | — | 1 | 6.07 |
| CHEMBL127782 | — | — | 1 | 5.99 |
| CHEMBL128523 | — | — | 1 | 5.82 |
| CHEMBL129090 | — | — | 1 | 5.65 |
| CHEMBL336630 | — | — | 1 | 5.41 |
| CHEMBL415234 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338157 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL338933 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2079714 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL130187 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL341484 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL130854 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL340937 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL338351 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL341496 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL340423 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL339600 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL340351 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL129690 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL129226 | — | IC50 | = | 612.0 | nM | 6.21 |
| CHEMBL340707 | — | IC50 | = | 613.0 | nM | 6.21 |
| CHEMBL129651 | — | IC50 | = | 853.0 | nM | 6.07 |
| CHEMBL127782 | — | IC50 | = | 1035.0 | nM | 5.99 |
| CHEMBL128523 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL129090 | — | IC50 | = | 2246.0 | nM | 5.65 |
| CHEMBL336630 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL415234 | — | IC50 | = | 145000.0 | nM | - |