Assay Detail
Functional
CHEMBL884138
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Competitive inhibition against [3H]dopamine uptake in bovine striatal tissue
7
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Tissue | Striatum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of 3-arylecgonine analogues as inhibitors of cocaine binding and dopamine uptake.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.95 | 6.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1790051 | — | — | 2 | 6.88 |
| CHEMBL302855 | — | — | 1 | 6.25 |
| CHEMBL60609 | — | — | 2 | 6.21 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.07 |
| CHEMBL62608 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1790051 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL302855 | — | IC50 | = | 557.0 | nM | 6.25 |
| CHEMBL60609 | — | IC50 | = | 616.0 | nM | 6.21 |
| CHEMBL370805 | COCAINE | IC50 | = | 843.0 | nM | 6.07 |
| CHEMBL60609 | — | IC50 | = | 903.0 | nM | 6.04 |
| CHEMBL1790051 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL62608 | — | IC50 | = | 30000.0 | nM | 4.52 |