Assay Detail
Functional
CHEMBL884196
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against herpes simplex virus type 1 (KOS strain) grown on human foreskin fibroblast cells determined by vedduction in plaque formation upon incubation at 37 degrees C with the compound dissolved in DMSO until plaque were formed
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
4-Oxo-4,7-dihydrothieno[2,3-b]pyridines as non-nucleoside inhibitors of human cytomegalovirus and related herpesvirus polymerases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.39 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL195453 | — | — | 1 | 5.52 |
| CHEMBL194433 | — | — | 1 | 5.46 |
| CHEMBL440033 | — | — | 1 | 5.43 |
| CHEMBL363625 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL195453 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL194433 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL440033 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL363625 | — | IC50 | = | 7400.0 | nM | 5.13 |