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Assay Detail

CHEMBL884228

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro antirhinoviral activity against human rhinovirus 25, inactive at 10 uM
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Enterovirus
Confidence 1 — Organism
Curated By Intermediate

Target

Enterovirus (CHEMBL613749)
Type ORGANISM
Organism Enterovirus

Publication

Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 8. Pharmacological optimization of orally bioavailable 2-pyridone-containing peptidomimetics.
Dragovich PS, Prins TJ, Zhou R, Johnson TO, Hua Y, Luu HT, Sakata SK, Brown EL, Maldonado FC, Tuntland T, Lee CA, Fuhrman SA, Zalman LS, Patick AK, Matthews DA, Wu EY, Guo M, Borer BC, Nayyar NK, Moran T, Chen L, Rejto PA, Rose PW, Guzman MC, Dovalsantos EZ, Lee S, McGee K, Mohajeri M, Liese A, Tao J, Kosa MB, Liu B, Batugo MR, Gleeson JP, Wu ZP, Liu J, Meador JW, Ferre RA.
J Med Chem (2003) 46 : 4572 -4585
PubMed 14521419 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 7.51 7.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL298019 PIRODAVIR 2.0 1 7.51

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL298019 PIRODAVIR EC50 = 31.0 nM 7.51