Assay Detail
Functional
CHEMBL884239
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Compound was tested in vitro against extracellular DNA hepatitis B virus of human liver cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and antiviral (HIV-1, HBV) activities of 5-halo-6-methoxy(or azido)-5,6-dihydro-3'-fluoro-3'-deoxythymidine diastereomers. Potential prodrugs to 3'-fluoro-3'-deoxythymidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.26 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL853 | ZALCITABINE | 4.0 | 1 | 5.89 |
| CHEMBL118427 | — | — | 1 | 5.22 |
| CHEMBL116767 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL853 | ZALCITABINE | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL118427 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL116767 | — | EC50 | = | 21000.0 | nM | 4.68 |