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Assay Detail

CHEMBL884248

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antifungal activity expressed as inhibitory concentration against Candida albicans CY1002 in YNBPB medium
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Candida albicans
Confidence 1 — Organism
Curated By Expert

Target

Candida albicans (CHEMBL366)
Type ORGANISM
Organism Candida albicans

Publication

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 2.
Ebiike H, Masubuchi M, Liu P, Kawasaki K, Morikami K, Sogabe S, Hayase M, Fujii T, Sakata K, Shindoh H, Shiratori Y, Aoki Y, Ohtsuka T, Shimma N.
Bioorg Med Chem Lett (2002) 12 : 607 -610
PubMed 11844682 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 6.45 7.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL158172 1 7.68
CHEMBL345893 1 7.52
CHEMBL347048 1 7.46
CHEMBL347895 1 7.40
CHEMBL158185 1 7.13
CHEMBL155301 1 7.10
CHEMBL154079 1 6.96
CHEMBL155469 1 6.80
CHEMBL346363 1 6.43
CHEMBL106 FLUCONAZOLE 4.0 1 6.14
CHEMBL433886 1 6.04
CHEMBL351774 1 5.92
CHEMBL301315 1 5.80
CHEMBL434276 1 4.96
CHEMBL155240 1 4.92
CHEMBL345610 1 4.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL158172 IC50 = 21.0 nM 7.68
CHEMBL345893 IC50 = 30.0 nM 7.52
CHEMBL347048 IC50 = 35.0 nM 7.46
CHEMBL347895 IC50 = 40.0 nM 7.40
CHEMBL158185 IC50 = 74.0 nM 7.13
CHEMBL155301 IC50 = 80.0 nM 7.10
CHEMBL154079 IC50 = 110.0 nM 6.96
CHEMBL155469 IC50 = 160.0 nM 6.80
CHEMBL346363 IC50 = 370.0 nM 6.43
CHEMBL106 FLUCONAZOLE IC50 = 720.0 nM 6.14
CHEMBL433886 IC50 = 920.0 nM 6.04
CHEMBL351774 IC50 = 1200.0 nM 5.92
CHEMBL301315 IC50 = 1600.0 nM 5.80
CHEMBL434276 IC50 = 11000.0 nM 4.96
CHEMBL155240 IC50 = 12000.0 nM 4.92
CHEMBL345610 IC50 = 13000.0 nM 4.89