Assay Detail
Functional
CHEMBL884252
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Antagonism of compound towards thyroid response element (TRAF alpha) in CHO-K1 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | CHO-K1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and preliminary characterization of a novel antiarrhythmic compound (KB130015) with an improved toxicity profile compared with amiodarone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.66 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157885 | — | — | 1 | 5.66 |
| CHEMBL160883 | — | — | 1 | - |
| CHEMBL160703 | — | — | 1 | - |
| CHEMBL633 | AMIODARONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157885 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL160883 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL160703 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL633 | AMIODARONE | IC50 | > | 10000.0 | nM | - |