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Assay Detail

CHEMBL884254

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Compound was evaluated for its inhibitory activity against the Calpain-1 enzyme
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Calpain-1 catalytic subunit (CHEMBL3891)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Dipeptidyl aspartyl fluoromethylketones as potent caspase-3 inhibitors: SAR of the P2 amino acid.
Wang Y, Huang JC, Zhou ZL, Yang W, Guastella J, Drewe J, Cai SX.
Bioorg Med Chem Lett (2004) 14 : 1269 -1272
PubMed 14980679 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.92 6.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL23453 1 6.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL23453 IC50 = 120.0 nM 6.92