Assay Detail
Binding
CHEMBL884261
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In vitro binding for inhibition of [125I]- Bolton-Hunter-CCK-8 binding in guinea pig cortex
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
CCK-A-selective tetrapeptides containing lys(N epsilon)-amide residues: favorable in vivo and in vitro effects of N-methylation at the aspartyl residue.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.55 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432864 | — | — | 1 | 6.89 |
| CHEMBL411466 | — | — | 1 | 6.15 |
| CHEMBL290143 | — | — | 1 | 6.14 |
| CHEMBL156559 | — | — | 1 | 5.37 |
| CHEMBL290142 | — | — | 1 | 5.34 |
| CHEMBL290936 | — | — | 1 | 5.24 |
| CHEMBL289744 | — | — | 1 | 4.98 |
| CHEMBL290034 | — | — | 1 | 4.96 |
| CHEMBL432293 | — | — | 1 | 4.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432864 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL411466 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL290143 | — | IC50 | = | 731.0 | nM | 6.14 |
| CHEMBL156559 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL290142 | — | IC50 | = | 4577.0 | nM | 5.34 |
| CHEMBL290936 | — | IC50 | = | 5810.0 | nM | 5.24 |
| CHEMBL289744 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL290034 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL432293 | — | IC50 | = | 13600.0 | nM | 4.87 |