Assay Detail
Binding
CHEMBL884351
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory potency against PGE-2 production in the human whole blood (HWB COX-2) assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Blood |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.41 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL322703 | — | — | 1 | 7.52 |
| CHEMBL110824 | — | — | 1 | 7.40 |
| CHEMBL107706 | — | — | 1 | 7.10 |
| CHEMBL108512 | — | — | 1 | 7.10 |
| CHEMBL110822 | — | — | 1 | 6.92 |
| CHEMBL322276 | — | — | 1 | 6.62 |
| CHEMBL323267 | — | — | 1 | 6.58 |
| CHEMBL320111 | — | — | 1 | 6.42 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 6.30 |
| CHEMBL122 | ROFECOXIB | 4.0 | 1 | 6.30 |
| CHEMBL110514 | — | — | 1 | 6.28 |
| CHEMBL321597 | — | — | 1 | 6.18 |
| CHEMBL326254 | — | — | 1 | 6.07 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.00 |
| CHEMBL106255 | — | — | 1 | 6.00 |
| CHEMBL319446 | — | — | 1 | 5.77 |
| CHEMBL108857 | — | — | 1 | 5.44 |
| CHEMBL320273 | — | — | 1 | 5.42 |
| CHEMBL320585 | — | — | 1 | - |
| CHEMBL322807 | — | — | 1 | - |
| CHEMBL108917 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL322703 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL110824 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL107706 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL108512 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL110822 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL322276 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL323267 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL320111 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL122 | ROFECOXIB | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL110514 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL321597 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL326254 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL118 | CELECOXIB | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL106255 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL319446 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL108857 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL320273 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL320585 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL322807 | — | IC50 | < | 400.0 | nM | - |
| CHEMBL108917 | — | IC50 | < | 400.0 | nM | - |