Assay Detail
Functional
CHEMBL884380
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to enhance [35S]GTP-gamma-S, binding to human Opioid receptor kappa expressed in CHO cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and in vitro pharmacological studies of C(4) modified salvinorin A analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.98 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290543 | — | — | 1 | 8.47 |
| CHEMBL196419 | — | — | 1 | 7.33 |
| CHEMBL196734 | — | — | 1 | 7.24 |
| CHEMBL197037 | — | — | 1 | 7.13 |
| CHEMBL362953 | — | — | 1 | 7.03 |
| CHEMBL383785 | — | — | 1 | 6.72 |
| CHEMBL415460 | — | — | 1 | 6.65 |
| CHEMBL263576 | — | — | 1 | 6.64 |
| CHEMBL196096 | — | — | 1 | 6.46 |
| CHEMBL194896 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290543 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL196419 | — | EC50 | = | 46.7 | nM | 7.33 |
| CHEMBL196734 | — | EC50 | = | 58.2 | nM | 7.24 |
| CHEMBL197037 | — | EC50 | = | 74.1 | nM | 7.13 |
| CHEMBL362953 | — | EC50 | = | 94.4 | nM | 7.03 |
| CHEMBL383785 | — | EC50 | = | 191.0 | nM | 6.72 |
| CHEMBL415460 | — | EC50 | = | 223.5 | nM | 6.65 |
| CHEMBL263576 | — | EC50 | = | 227.0 | nM | 6.64 |
| CHEMBL196096 | — | EC50 | = | 348.0 | nM | 6.46 |
| CHEMBL194896 | — | EC50 | = | 840.0 | nM | 6.08 |