Assay Detail
Binding
CHEMBL884433
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Inhibitory concentration against dihydrofolate reductace enzyme of Pneumocystis carinii
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pneumocystis carinii |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
New 2,4-diamino-5-(2',5'-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.87 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 7.89 |
| CHEMBL35020 | — | — | 1 | 7.64 |
| CHEMBL288350 | — | — | 1 | 6.28 |
| CHEMBL288647 | — | — | 1 | 6.05 |
| CHEMBL284839 | — | — | 1 | 5.96 |
| CHEMBL290806 | — | — | 1 | 5.92 |
| CHEMBL34293 | — | — | 1 | 5.89 |
| CHEMBL35437 | — | — | 1 | 5.64 |
| CHEMBL34378 | — | — | 1 | 5.39 |
| CHEMBL35080 | — | — | 1 | 5.25 |
| CHEMBL38158 | — | — | 1 | 5.15 |
| CHEMBL289908 | — | — | 1 | 5.11 |
| CHEMBL34641 | — | — | 1 | 5.07 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7492 | PIRITREXIM | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL35020 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL288350 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL288647 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL284839 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL290806 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL34293 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL35437 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL34378 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL35080 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL38158 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL289908 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL34641 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 12000.0 | nM | 4.92 |