Assay Detail
Binding
CHEMBL884530
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]ketanserin binding at 5-hydroxytryptamine 2 receptor from rat frontal cortex.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Serotonin 2 (5-HT2) receptor (CHEMBL2093870) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Effect of linking bridge modifications on the antipsychotic profile of some phthalimide and isoindolinone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 8.13 | 9.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38409 | — | — | 1 | 9.16 |
| CHEMBL290953 | — | — | 1 | 9.11 |
| CHEMBL291070 | — | — | 1 | 8.77 |
| CHEMBL288450 | — | — | 1 | 8.77 |
| CHEMBL41536 | — | — | 1 | 8.74 |
| CHEMBL41636 | — | — | 1 | 8.66 |
| CHEMBL43069 | — | — | 1 | 8.49 |
| CHEMBL288930 | — | — | 1 | 8.40 |
| CHEMBL41626 | — | — | 1 | 8.29 |
| CHEMBL38747 | — | — | 1 | 8.27 |
| CHEMBL43410 | — | — | 1 | 8.26 |
| CHEMBL39226 | — | — | 1 | 8.22 |
| CHEMBL290937 | — | — | 1 | 8.12 |
| CHEMBL36423 | — | — | 1 | 8.01 |
| CHEMBL441430 | — | — | 1 | 7.89 |
| CHEMBL559330 | — | — | 1 | 7.75 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.55 |
| CHEMBL289275 | — | — | 1 | 7.52 |
| CHEMBL43513 | — | — | 1 | 7.37 |
| CHEMBL41309 | — | — | 1 | 6.92 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38409 | — | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL290953 | — | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL291070 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL288450 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL41536 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL41636 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL43069 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL288930 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL41626 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL38747 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL43410 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL39226 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL290937 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL36423 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL441430 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL559330 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL289275 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL43513 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL41309 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 360.0 | nM | 6.44 |