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Assay Detail

CHEMBL884568

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity af the compound towards cathepsin D
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Cathepsin D (CHEMBL2581)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Hydroxyethylene sulfones as a new scaffold to address aspartic proteases: design, synthesis, and structural characterization.
Specker E, Böttcher J, Heine A, Sotriffer CA, Lilie H, Schoop A, Müller G, Griebenow N, Klebe G.
J Med Chem (2005) 48 : 6607 -6619
PubMed 16220977 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 10.15 10.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL81927 1 10.15

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL81927 Ki = 0.07 nM 10.15