Assay Detail
Binding
CHEMBL884737
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Inhibition constant against human recombinant Monoamine oxidase-B
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Docking studies on monoamine oxidase-B inhibitors: estimation of inhibition constants (K(i)) of a series of experimentally tested compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.66 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279390 | LAZABEMIDE | 2.0 | 1 | 7.08 |
| CHEMBL436947 | — | — | 1 | 6.22 |
| CHEMBL198810 | — | — | 1 | 6.22 |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 6.16 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 6.01 |
| CHEMBL673 | PARGYLINE | 4.0 | 1 | 5.75 |
| CHEMBL326294 | ISATIN | — | 1 | 5.52 |
| CHEMBL348961 | — | — | 1 | 4.85 |
| CHEMBL371428 | — | — | 1 | 4.77 |
| CHEMBL194732 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279390 | LAZABEMIDE | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL436947 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL198810 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL887 | RASAGILINE | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL972 | SELEGILINE | Ki | = | 970.0 | nM | 6.01 |
| CHEMBL673 | PARGYLINE | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL326294 | ISATIN | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL348961 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL371428 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL194732 | — | Ki | = | 100000.0 | nM | 4.00 |