Assay Detail
Binding
CHEMBL884781
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Binding affinity towards Dopamine D2S receptor using CHO cell line and [3H]spiperone as radioligand
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and evaluation of 18F-labeled dopamine D3 receptor ligands as potential PET imaging agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.91 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL196744 | — | — | 1 | 7.75 |
| CHEMBL197162 | — | — | 1 | 7.54 |
| CHEMBL195247 | — | — | 1 | 7.31 |
| CHEMBL197195 | — | — | 1 | 7.24 |
| CHEMBL194755 | — | — | 1 | 6.92 |
| CHEMBL194727 | — | — | 1 | 6.85 |
| CHEMBL198993 | — | — | 1 | 6.62 |
| CHEMBL197214 | — | — | 1 | 6.40 |
| CHEMBL59725 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL196744 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL197162 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL195247 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL197195 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL194755 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL194727 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL198993 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL197214 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL59725 | — | Ki | = | 2600.0 | nM | 5.58 |