Assay Detail
Binding
CHEMBL884811
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In vitro binding affinity towards cloned human 5-HT1B receptor using [3H]5-carboximidotryptamine as radioligand
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis of potent and selective serotonin 5-HT1B receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.94 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL372453 | — | — | 1 | 8.74 |
| CHEMBL15928 | GR-127935 | — | 1 | 8.37 |
| CHEMBL195927 | — | — | 1 | 8.01 |
| CHEMBL281350 | SB-224289 | — | 1 | 8.00 |
| CHEMBL370128 | — | — | 1 | 7.95 |
| CHEMBL196370 | — | — | 1 | 7.91 |
| CHEMBL197408 | — | — | 1 | 7.86 |
| CHEMBL197796 | — | — | 1 | 7.78 |
| CHEMBL196169 | — | — | 1 | 7.74 |
| CHEMBL196598 | — | — | 1 | 7.55 |
| CHEMBL194206 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL372453 | — | Ki | = | 1.82 | nM | 8.74 |
| CHEMBL15928 | GR-127935 | Ki | = | 4.31 | nM | 8.37 |
| CHEMBL195927 | — | Ki | = | 9.68 | nM | 8.01 |
| CHEMBL281350 | SB-224289 | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL370128 | — | Ki | = | 11.3 | nM | 7.95 |
| CHEMBL196370 | — | Ki | = | 12.4 | nM | 7.91 |
| CHEMBL197408 | — | Ki | = | 13.7 | nM | 7.86 |
| CHEMBL197796 | — | Ki | = | 16.7 | nM | 7.78 |
| CHEMBL196169 | — | Ki | = | 18.1 | nM | 7.74 |
| CHEMBL196598 | — | Ki | = | 28.4 | nM | 7.55 |
| CHEMBL194206 | — | Ki | = | 38.3 | nM | 7.42 |