Assay Detail
Functional
CHEMBL884926
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Inhibition of 10 nM 2-MeS-ADP-stimulated phospholipase C in turkey erythrocyte membranes using [3H]inositol
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Meleagris gallopavo |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Structure-activity relationships of pyridoxal phosphate derivatives as potent and selective antagonists of P2X1 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.35 | 4.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119416 | — | — | 1 | 4.84 |
| CHEMBL69234 | — | — | 1 | 4.78 |
| CHEMBL69727 | ISOPPADS | — | 1 | 4.67 |
| CHEMBL331250 | — | — | 1 | 4.57 |
| CHEMBL118007 | — | — | 1 | 4.27 |
| CHEMBL119235 | — | — | 1 | 4.00 |
| CHEMBL117766 | — | — | 1 | 4.00 |
| CHEMBL445630 | — | — | 1 | 4.00 |
| CHEMBL331238 | — | — | 1 | 4.00 |
| CHEMBL331439 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119416 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL69234 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL69727 | ISOPPADS | IC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL331250 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL118007 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL119235 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL117766 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL445630 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL331238 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL331439 | — | IC50 | > | 100000.0 | nM | - |