Assay Detail
Binding
CHEMBL884932
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for rat estrogen receptor beta
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A selective estrogen receptor modulator designed for the treatment of uterine leiomyoma with unique tissue specificity for uterus and ovaries in rats.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.74 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL537638 | — | — | 1 | 9.52 |
| CHEMBL539849 | — | — | 1 | 9.15 |
| CHEMBL536733 | — | — | 1 | 8.87 |
| CHEMBL1116 | RALOXIFENE HYDROCHLORIDE | 4.0 | 1 | 8.56 |
| CHEMBL557981 | — | — | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL537638 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL539849 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL536733 | — | Ki | = | 1.36 | nM | 8.87 |
| CHEMBL1116 | RALOXIFENE HYDROCHLORIDE | Ki | = | 2.74 | nM | 8.56 |
| CHEMBL557981 | — | Ki | = | 24.1 | nM | 7.62 |