Assay Detail

CHEMBL884937

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Binding

Negative logarithm of the drug concentration against H2 histamine receptor

ChEMBL ↗

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Target

Histamine H2 receptor (CHEMBL1941) ↗

Open DB target context

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Histamine H2 receptor (CHEMBL1941) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Histamine H2 receptor

CHEMBL1941

Anchored from Assay target.

Protein identity Histamine H2 receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Expert

Target

Histamine H2 receptor (CHEMBL1941) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Designed multiple ligands. An emerging drug discovery paradigm.

Morphy R, Rankovic Z.
J Med Chem (2005) 48 : 6523 -6543
PubMed 16220969 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	2	6.60	6.60

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL46102	ROXATIDINE ACETATE	-1.0	1	6.60
CHEMBL196143	—	—	1	6.60

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL46102	ROXATIDINE ACETATE	Kd	=	251.19	nM	6.60
CHEMBL196143	—	Kd	=	251.19	nM	6.60