Assay Detail
Functional
CHEMBL885033
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against non-receptor tyrosine kinase Src in cell assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of Src kinase activity by 7-[(2,4-dichloro-5-methoxyphenyl)amino]-2-heteroaryl-thieno[3,2-b]pyridine-6-carbonitriles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.12 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 7.00 |
| CHEMBL197094 | — | — | 1 | 6.58 |
| CHEMBL370693 | — | — | 1 | 6.44 |
| CHEMBL373101 | — | — | 1 | 6.38 |
| CHEMBL194664 | — | — | 1 | 6.37 |
| CHEMBL193452 | — | — | 1 | 6.19 |
| CHEMBL364955 | — | — | 1 | 6.14 |
| CHEMBL193392 | — | — | 1 | 5.92 |
| CHEMBL193695 | — | — | 1 | 5.72 |
| CHEMBL192652 | — | — | 1 | 5.62 |
| CHEMBL372178 | — | — | 1 | 5.54 |
| CHEMBL370371 | — | — | 1 | 5.51 |
| CHEMBL193751 | — | — | 1 | - |
| CHEMBL194674 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288441 | BOSUTINIB | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL197094 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL370693 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL373101 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL194664 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL193452 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL364955 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL193392 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL193695 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL192652 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL372178 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL370371 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL193751 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL194674 | — | IC50 | > | 5000.0 | nM | - |