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Assay Detail

CHEMBL885057

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Concentration producing half-maximal inhibition of specific binding of [125I]- CCK-8 to CCK receptors on mouse pancreatic membranes (CCK-A)
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Cholecystokinin receptor type A (CHEMBL2798)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Novel cholecystokinin receptor ligands: Oxopiperazines derived from Boc-CCK-4
Batt AR, Kendrick DA, Mathews E, Rooker DP, Ryder H, Semple G, Szelke M
Bioorg Med Chem Lett (1994) 4 : 867 -872
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 5.74 7.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL355608 1 7.85
CHEMBL171310 1 7.34
CHEMBL169174 1 7.19
CHEMBL354363 1 6.57
CHEMBL169178 1 6.37
CHEMBL353148 1 6.28
CHEMBL355778 1 6.20
CHEMBL170026 1 6.08
CHEMBL170207 1 5.85
CHEMBL172135 1 5.55
CHEMBL278032 1 5.46
CHEMBL435339 1 5.44
CHEMBL441840 1 5.26
CHEMBL172177 1 5.20
CHEMBL171051 1 5.14
CHEMBL172635 1 5.03
CHEMBL424370 1 4.89
CHEMBL170197 1 4.62
CHEMBL436451 1 4.29
CHEMBL172354 1 4.25

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL355608 IC50 = 14.0 nM 7.85
CHEMBL171310 IC50 = 46.0 nM 7.34
CHEMBL169174 IC50 = 64.0 nM 7.19
CHEMBL354363 IC50 = 270.0 nM 6.57
CHEMBL169178 IC50 = 430.0 nM 6.37
CHEMBL353148 IC50 = 520.0 nM 6.28
CHEMBL355778 IC50 = 630.0 nM 6.20
CHEMBL170026 IC50 = 840.0 nM 6.08
CHEMBL170207 IC50 = 1400.0 nM 5.85
CHEMBL172135 IC50 = 2800.0 nM 5.55
CHEMBL278032 IC50 = 3500.0 nM 5.46
CHEMBL435339 IC50 = 3600.0 nM 5.44
CHEMBL441840 IC50 = 5500.0 nM 5.26
CHEMBL172177 IC50 = 6300.0 nM 5.20
CHEMBL171051 IC50 = 7200.0 nM 5.14
CHEMBL172635 IC50 = 9400.0 nM 5.03
CHEMBL424370 IC50 = 13000.0 nM 4.89
CHEMBL170197 IC50 = 24000.0 nM 4.62
CHEMBL436451 IC50 = 51000.0 nM 4.29
CHEMBL172354 IC50 = 56000.0 nM 4.25