Assay Detail
Binding
CHEMBL885075
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In vitro inhibitory activity towards [3H]cocaine binding to rat striatal tissue
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of 3-carbamoylecgonine methyl ester analogues as inhibitors of cocaine binding and dopamine uptake.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.95 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159325 | — | — | 1 | 7.43 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 7.19 |
| CHEMBL163614 | — | — | 1 | 5.96 |
| CHEMBL350155 | — | — | 1 | 5.68 |
| CHEMBL164409 | — | — | 1 | 5.25 |
| CHEMBL348799 | — | — | 1 | 4.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159325 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL370805 | COCAINE | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL163614 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL350155 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL164409 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL348799 | — | IC50 | = | 63300.0 | nM | 4.20 |