Assay Detail
Binding
CHEMBL885077
Review assay metadata, readout intent, target linkage, and publication context from the same page.
50% in vitro inhibitory concentration against Cytochrome P450 19A1 from human placental microsomes by thiobarbituric acid assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Microsome |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1-imidazolyl(alkyl)-substituted di- and tetrahydroquinolines and analogues: syntheses and evaluation of dual inhibitors of thromboxane A(2) synthase and aromatase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.05 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300109 | — | — | 1 | 6.80 |
| CHEMBL53068 | — | — | 1 | 6.77 |
| CHEMBL53290 | — | — | 1 | 6.66 |
| CHEMBL54803 | — | — | 1 | 6.46 |
| CHEMBL301106 | — | — | 1 | 6.46 |
| CHEMBL292899 | — | — | 1 | 6.42 |
| CHEMBL291700 | — | — | 1 | 6.36 |
| CHEMBL293122 | — | — | 1 | 6.30 |
| CHEMBL57513 | — | — | 1 | 6.17 |
| CHEMBL53644 | — | — | 1 | 6.16 |
| CHEMBL55144 | — | — | 1 | 6.04 |
| CHEMBL298720 | — | — | 1 | 5.86 |
| CHEMBL55083 | — | — | 1 | 5.62 |
| CHEMBL299066 | — | — | 1 | 5.51 |
| CHEMBL460382 | — | — | 1 | 5.45 |
| CHEMBL55558 | — | — | 1 | 5.41 |
| CHEMBL56059 | — | — | 1 | 5.22 |
| CHEMBL52509 | — | — | 1 | 5.19 |
| CHEMBL301608 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300109 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL53068 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL53290 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL54803 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL301106 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL292899 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL291700 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL293122 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL57513 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL53644 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL55144 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL298720 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL55083 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL299066 | — | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL460382 | — | IC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL55558 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL56059 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL52509 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL301608 | — | IC50 | = | 111000.0 | nM | - |