Assay Detail
Functional
CHEMBL885080
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against estrogen-induced proliferation of Ishikawa uterine cells by 1 nM E2
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Ishikawa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
A selective estrogen receptor modulator designed for the treatment of uterine leiomyoma with unique tissue specificity for uterus and ovaries in rats.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.42 | 8.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL539849 | — | — | 1 | 8.94 |
| CHEMBL537638 | — | — | 1 | 8.50 |
| CHEMBL1116 | RALOXIFENE HYDROCHLORIDE | 4.0 | 1 | 8.37 |
| CHEMBL557981 | — | — | 1 | 8.32 |
| CHEMBL536733 | — | — | 1 | 7.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL539849 | — | IC50 | = | 1.14 | nM | 8.94 |
| CHEMBL537638 | — | IC50 | = | 3.18 | nM | 8.50 |
| CHEMBL1116 | RALOXIFENE HYDROCHLORIDE | IC50 | = | 4.32 | nM | 8.37 |
| CHEMBL557981 | — | IC50 | = | 4.78 | nM | 8.32 |
| CHEMBL536733 | — | IC50 | = | 10.7 | nM | 7.97 |