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Assay Detail

CHEMBL885081

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory concentration against amastigotes of Leishmania donovani strain MHOM/ET/67/L82 upon incubation at 37 degrees C for 2 hours using alamar blue
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania donovani
Confidence 1 — Organism
Curated By Expert

Target

Leishmania donovani (CHEMBL367)
Type ORGANISM
Organism Leishmania donovani

Publication

Analogues of thiolactomycin as potential antimalarial agents.
Jones SM, Urch JE, Kaiser M, Brun R, Harwood JL, Berry C, Gilbert IH.
J Med Chem (2005) 48 : 5932 -5941
PubMed 16161997 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 4.89 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL194317 1 6.30
CHEMBL371411 1 6.00
CHEMBL427000 1 5.70
CHEMBL370373 1 5.52
CHEMBL197925 1 5.16
CHEMBL197622 1 4.92
CHEMBL370442 1 4.44
CHEMBL196418 1 4.25
CHEMBL366184 1 4.18
CHEMBL197886 1 4.09
CHEMBL196053 1 4.06
CHEMBL197258 1 4.00
CHEMBL194456 1 -
CHEMBL194262 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL194317 IC50 = 500.0 nM 6.30
CHEMBL371411 IC50 = 1000.0 nM 6.00
CHEMBL427000 IC50 = 2000.0 nM 5.70
CHEMBL370373 IC50 = 3000.0 nM 5.52
CHEMBL197925 IC50 = 7000.0 nM 5.16
CHEMBL197622 IC50 = 12000.0 nM 4.92
CHEMBL370442 IC50 = 36000.0 nM 4.44
CHEMBL196418 IC50 = 56000.0 nM 4.25
CHEMBL366184 IC50 = 66000.0 nM 4.18
CHEMBL197886 IC50 = 82000.0 nM 4.09
CHEMBL196053 IC50 = 88000.0 nM 4.06
CHEMBL197258 IC50 = 100000.0 nM 4.00
CHEMBL194456 IC50 > 66000.0 nM -
CHEMBL194262 IC50 > 74000.0 nM -