Assay Detail
Functional
CHEMBL885194
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration against US28-mediated inositol phosphate production in COS-7 cells
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | COS-7 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
G-protein coupled receptor homolog US28 (CHEMBL4259) ↗| Type | SINGLE PROTEIN |
| Organism | Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) |
Publication
Synthesis and structure-activity relationship of the first nonpeptidergic inverse agonists for the human cytomegalovirus encoded chemokine receptor US28.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 4.97 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34166 | BERLEX COMPOUND | — | 1 | 5.50 |
| CHEMBL198935 | — | — | 1 | 5.38 |
| CHEMBL198553 | — | — | 1 | 5.01 |
| CHEMBL370577 | — | — | 1 | 4.94 |
| CHEMBL198505 | — | — | 1 | 4.86 |
| CHEMBL195943 | — | — | 1 | 4.55 |
| CHEMBL141713 | — | — | 1 | 4.54 |
| CHEMBL380793 | — | — | 1 | - |
| CHEMBL422115 | — | — | 1 | - |
| CHEMBL197978 | — | — | 1 | - |
| CHEMBL198503 | — | — | 1 | - |
| CHEMBL199034 | — | — | 1 | - |
| CHEMBL198308 | — | — | 1 | - |
| CHEMBL198449 | — | — | 1 | - |
| CHEMBL199065 | — | — | 1 | - |
| CHEMBL199252 | — | — | 1 | - |
| CHEMBL197342 | — | — | 1 | - |
| CHEMBL370660 | — | — | 1 | - |
| CHEMBL372756 | — | — | 1 | - |
| CHEMBL199035 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34166 | BERLEX COMPOUND | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL198935 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL198553 | — | EC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL370577 | — | EC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL198505 | — | EC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL195943 | — | EC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL141713 | — | EC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL380793 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL422115 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL197978 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL198503 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL199034 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL198308 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL198449 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL199065 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL199252 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL197342 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL370660 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL372756 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL199035 | — | EC50 | > | 100000.0 | nM | - |