Assay Detail
Functional
CHEMBL885339
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Tested for functional activity against neuronal nicotinic acetylcholine receptor(nAChR) expressed in IMR-32 cells using isotopic rubidium efflux assay.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IMR-32 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel 2-(2-furo[3,2-b]pyridinyl) pyrrolidines: potent neuronal nicotinic acetylcholine receptor ligands
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 4.47 | 4.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3 | NICOTINE | 4.0 | 1 | 4.68 |
| CHEMBL84149 | — | — | 1 | 4.62 |
| CHEMBL328323 | — | — | 1 | 4.38 |
| CHEMBL274525 | ABT-418 | — | 1 | 4.19 |
| CHEMBL91005 | — | — | 1 | - |
| CHEMBL93883 | — | — | 1 | - |
| CHEMBL327441 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3 | NICOTINE | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL84149 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL328323 | — | EC50 | = | 41500.0 | nM | 4.38 |
| CHEMBL274525 | ABT-418 | EC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL91005 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL93883 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL327441 | — | EC50 | > | 1000000.0 | nM | - |