Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL885362

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity for 1 uM [3H]diprenorphine against human Opioid receptor kappa expressed in chinese hamster ovary cells (CHO cells)
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Expert

Target

Kappa-type opioid receptor (CHEMBL237)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and in vitro pharmacological studies of C(4) modified salvinorin A analogues.
Lee DY, He M, Kondaveti L, Liu-Chen LY, Ma Z, Wang Y, Chen Y, Li JG, Beguin C, Carlezon WA, Cohen B.
Bioorg Med Chem Lett (2005) 15 : 4169 -4173
PubMed 16051487 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 32 7.13 8.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL290543 1 8.85
CHEMBL196419 1 7.57
CHEMBL362953 1 7.54
CHEMBL197037 1 7.31
CHEMBL196734 1 7.00
CHEMBL383785 1 6.96
CHEMBL415460 1 6.70
CHEMBL196096 1 6.68
CHEMBL263576 1 6.33
CHEMBL194896 1 6.32
CHEMBL426094 1 -
CHEMBL371626 1 -
CHEMBL196735 1 -
CHEMBL194210 1 -
CHEMBL196045 1 -
CHEMBL194264 1 -
CHEMBL195977 1 -
CHEMBL365814 1 -
CHEMBL372723 1 -
CHEMBL370716 1 -
CHEMBL371745 1 -
CHEMBL196429 1 -
CHEMBL194179 1 -
CHEMBL373176 1 -
CHEMBL370546 1 -
CHEMBL438803 1 -
CHEMBL195594 1 -
CHEMBL196097 1 -
CHEMBL193690 1 -
CHEMBL370982 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL290543 Ki = 1.4 nM 8.85
CHEMBL196419 Ki = 26.9 nM 7.57
CHEMBL362953 Ki = 28.5 nM 7.54
CHEMBL197037 Ki = 48.6 nM 7.31
CHEMBL196734 Ki = 99.6 nM 7.00
CHEMBL383785 Ki = 110.0 nM 6.96
CHEMBL415460 Ki = 201.0 nM 6.70
CHEMBL196096 Ki = 210.0 nM 6.68
CHEMBL263576 Ki = 470.0 nM 6.33
CHEMBL194896 Ki = 475.0 nM 6.32
CHEMBL371626 Ki > 1000.0 nM -
CHEMBL196735 Ki > 1000.0 nM -
CHEMBL194210 Ki > 1000.0 nM -
CHEMBL196045 Ki > 1000.0 nM -
CHEMBL194264 Ki > 1000.0 nM -
CHEMBL195977 Ki > 1000.0 nM -
CHEMBL365814 Ki > 1000.0 nM -
CHEMBL372723 Ki > 1000.0 nM -
CHEMBL370716 Ki > 1000.0 nM -
CHEMBL193815 Ki > 1000.0 nM -
CHEMBL193680 Ki > 1000.0 nM -
CHEMBL426094 Ki > 1000.0 nM -
CHEMBL371745 Ki > 1000.0 nM -
CHEMBL196429 Ki > 1000.0 nM -
CHEMBL194179 Ki > 1000.0 nM -
CHEMBL373176 Ki > 1000.0 nM -
CHEMBL370546 Ki > 1000.0 nM -
CHEMBL438803 Ki > 1000.0 nM -
CHEMBL195594 Ki > 1000.0 nM -
CHEMBL196097 Ki > 1000.0 nM -
CHEMBL193690 Ki > 1000.0 nM -
CHEMBL370982 Ki > 1000.0 nM -