Assay Detail
Binding
CHEMBL885375
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Binding affinity towards human dopamine receptor 4.4 expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligand
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | ovary |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pharmacophore-guided drug discovery investigations leading to bioactive 5-aminotetrahydropyrazolopyridines. Implications for the binding mode of heterocyclic dopamine D3 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 4.65 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL197159 | — | — | 1 | 4.89 |
| CHEMBL198174 | — | — | 1 | 4.85 |
| CHEMBL198125 | — | — | 1 | 4.80 |
| CHEMBL383805 | — | — | 1 | 4.05 |
| CHEMBL198303 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL197159 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL198174 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL198125 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL383805 | — | Ki | = | 90000.0 | nM | 4.05 |
| CHEMBL198303 | — | Ki | > | 20000.0 | nM | - |