Assay Detail
Binding
CHEMBL885422
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Inhibition of COX2 in canine whole blood
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Tissue | Blood |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part III: molecular modeling studies on binding contribution of 1-(5-methylsulfonyl)pyrid-2-yl and 4-nitrile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 6.70 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370579 | — | — | 1 | 7.52 |
| CHEMBL248096 | — | — | 1 | 7.22 |
| CHEMBL248502 | — | — | 1 | 7.16 |
| CHEMBL204859 | — | — | 1 | 7.10 |
| CHEMBL245641 | — | — | 1 | 7.10 |
| CHEMBL248503 | — | — | 1 | 7.05 |
| CHEMBL199992 | — | — | 1 | 6.96 |
| CHEMBL383207 | — | — | 1 | 6.96 |
| CHEMBL247870 | — | — | 1 | 6.92 |
| CHEMBL393711 | — | — | 1 | 6.92 |
| CHEMBL392244 | — | — | 1 | 6.80 |
| CHEMBL394096 | — | — | 1 | 6.77 |
| CHEMBL381879 | — | — | 1 | 6.70 |
| CHEMBL382484 | — | — | 1 | 6.68 |
| CHEMBL393709 | — | — | 1 | 6.64 |
| CHEMBL248302 | — | — | 1 | 6.62 |
| CHEMBL392243 | — | — | 1 | 6.62 |
| CHEMBL174219 | — | — | 1 | 6.51 |
| CHEMBL175826 | — | — | 1 | 6.39 |
| CHEMBL382013 | — | — | 1 | 5.39 |
| CHEMBL241744 | — | — | 1 | 4.71 |
| CHEMBL248301 | — | — | 1 | - |
| CHEMBL392030 | — | — | 1 | - |
| CHEMBL248303 | — | — | 1 | - |
| CHEMBL248097 | — | — | 1 | - |
| CHEMBL394095 | — | — | 1 | - |
| CHEMBL247896 | — | — | 1 | - |
| CHEMBL245442 | — | — | 1 | - |
| CHEMBL393096 | — | — | 1 | - |
| CHEMBL391445 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370579 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL248096 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL248502 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL204859 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL245641 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL248503 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL199992 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL383207 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL247870 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL393711 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL392244 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL394096 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL381879 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL382484 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL393709 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL392243 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL248302 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL174219 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL175826 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL382013 | — | IC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL241744 | — | IC50 | = | 19640.0 | nM | 4.71 |
| CHEMBL241743 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL245440 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL241742 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL426846 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL398802 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL248504 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL400825 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL239797 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL239796 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL241737 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL245441 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL393710 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL393097 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL245608 | — | IC50 | < | 500.0 | nM | - |
| CHEMBL245609 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL391445 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL393096 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL245442 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL247896 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL394095 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL248097 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL248303 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL392030 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL248301 | — | IC50 | > | 500.0 | nM | - |