Assay Detail
Binding
CHEMBL885471
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Inhibition of [3H]WIN-uptake in human DAT expressed in CHO cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.29 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL246955 | — | — | 1 | 7.54 |
| CHEMBL395368 | — | — | 1 | 7.34 |
| CHEMBL395609 | — | — | 1 | 6.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL246955 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL395368 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL395609 | — | Ki | = | 102.0 | nM | 6.99 |