Assay Detail
Functional
CHEMBL885478
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Cytotoxicity against human HeLa cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and cytotoxic activities of 4,5-diarylisoxazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.37 | 10.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL240198 | — | — | 1 | 10.66 |
| CHEMBL392582 | — | — | 1 | 9.05 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.56 |
| CHEMBL239769 | — | — | 1 | 8.33 |
| CHEMBL239987 | — | — | 1 | 7.94 |
| CHEMBL240199 | — | — | 1 | 7.53 |
| CHEMBL392470 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL240198 | — | IC50 | = | 0.022 | nM | 10.66 |
| CHEMBL392582 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2.75 | nM | 8.56 |
| CHEMBL239769 | — | IC50 | = | 4.69 | nM | 8.33 |
| CHEMBL239987 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL240199 | — | IC50 | = | 29.4 | nM | 7.53 |
| CHEMBL392470 | — | IC50 | = | 299.0 | nM | 6.52 |