Assay Detail
Functional
CHEMBL885479
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Cytotoxicity against human HepG2 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and cytotoxic activities of 4,5-diarylisoxazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.43 | 10.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL240198 | — | — | 1 | 10.19 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 9.85 |
| CHEMBL392582 | — | — | 1 | 8.85 |
| CHEMBL239769 | — | — | 1 | 8.36 |
| CHEMBL239987 | — | — | 1 | 7.86 |
| CHEMBL240199 | — | — | 1 | 7.47 |
| CHEMBL392470 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL240198 | — | IC50 | = | 0.065 | nM | 10.19 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL392582 | — | IC50 | = | 1.43 | nM | 8.85 |
| CHEMBL239769 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL239987 | — | IC50 | = | 13.7 | nM | 7.86 |
| CHEMBL240199 | — | IC50 | = | 33.9 | nM | 7.47 |
| CHEMBL392470 | — | IC50 | = | 396.0 | nM | 6.40 |