Assay Detail
Binding
CHEMBL885667
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Inhibition of human ACAT2 expressed in Hi5 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BTI-TN-5B1-4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Human ACAT inhibitory effects of shikonin derivatives from Lithospermum erythrorhizon.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.31 | 4.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL395857 | — | — | 1 | 4.60 |
| CHEMBL8951 | — | — | 1 | 4.54 |
| CHEMBL8806 | — | — | 1 | 4.30 |
| CHEMBL8805 | — | — | 1 | 4.25 |
| CHEMBL9416 | ISOBUTYLSHIKONIN | — | 1 | 4.24 |
| CHEMBL276448 | — | — | 1 | 4.15 |
| CHEMBL9499 | — | — | 1 | 4.07 |
| CHEMBL403516 | ACETYLSHIKONIN | — | 1 | - |
| CHEMBL9470 | SHIKONIN | — | 1 | - |
| CHEMBL397309 | BETA-HYDROXYISOVALERYLSHIKONIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL395857 | — | IC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL8951 | — | IC50 | = | 28700.0 | nM | 4.54 |
| CHEMBL8806 | — | IC50 | = | 49600.0 | nM | 4.30 |
| CHEMBL8805 | — | IC50 | = | 56200.0 | nM | 4.25 |
| CHEMBL9416 | ISOBUTYLSHIKONIN | IC50 | = | 57500.0 | nM | 4.24 |
| CHEMBL276448 | — | IC50 | = | 71400.0 | nM | 4.15 |
| CHEMBL9499 | — | IC50 | = | 84500.0 | nM | 4.07 |
| CHEMBL403516 | ACETYLSHIKONIN | IC50 | = | 112200.0 | nM | - |
| CHEMBL9470 | SHIKONIN | IC50 | = | 138200.0 | nM | - |
| CHEMBL397309 | BETA-HYDROXYISOVALERYLSHIKONIN | IC50 | = | 169800.0 | nM | - |