Assay Detail
Functional
CHEMBL885694
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Antagonist activity at NMDA receptor in ICR mouse synaptoneurosome assessed as inhibition of NMDA/Gly-mediated 45-calcium influx
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity relationships of pentacycloundecylamines at the N-methyl-d-aspartate receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.00 | 5.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284237 | DIZOCILPINE | 2.0 | 1 | 5.91 |
| CHEMBL391409 | — | — | 1 | 5.53 |
| CHEMBL807 | MEMANTINE | 4.0 | 1 | 5.52 |
| CHEMBL391410 | — | — | 1 | 5.39 |
| CHEMBL392128 | — | — | 1 | 4.68 |
| CHEMBL240981 | — | — | 1 | 4.63 |
| CHEMBL392955 | — | — | 1 | 4.48 |
| CHEMBL240328 | — | — | 1 | 4.44 |
| CHEMBL240113 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284237 | DIZOCILPINE | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL391409 | — | IC50 | = | 2980.0 | nM | 5.53 |
| CHEMBL807 | MEMANTINE | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL391410 | — | IC50 | = | 4060.0 | nM | 5.39 |
| CHEMBL392128 | — | IC50 | = | 20650.0 | nM | 4.68 |
| CHEMBL240981 | — | IC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL392955 | — | IC50 | = | 32780.0 | nM | 4.48 |
| CHEMBL240328 | — | IC50 | = | 36220.0 | nM | 4.44 |
| CHEMBL240113 | — | IC50 | = | 37620.0 | nM | 4.42 |