Assay Detail
Binding
CHEMBL885887
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Displacement of [3H]spiperone from human cloned dopamine D2L receptor expressed in CHO cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Dopamine/serotonin receptor ligands. Part 15: Oxygenation of the benz-indolo-azecine LE 300 leads to novel subnanomolar dopamine D1/D5 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.68 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL245764 | — | — | 1 | 8.77 |
| CHEMBL396560 | — | — | 1 | 7.92 |
| CHEMBL380330 | — | — | 1 | 7.89 |
| CHEMBL201170 | — | — | 1 | 7.76 |
| CHEMBL396561 | — | — | 1 | 7.64 |
| CHEMBL245570 | — | — | 1 | 7.42 |
| CHEMBL441618 | — | — | 1 | 7.35 |
| CHEMBL201525 | — | — | 1 | 7.25 |
| CHEMBL245571 | — | — | 1 | 7.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL245764 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL396560 | — | Ki | = | 11.9 | nM | 7.92 |
| CHEMBL380330 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL201170 | — | Ki | = | 17.5 | nM | 7.76 |
| CHEMBL396561 | — | Ki | = | 22.8 | nM | 7.64 |
| CHEMBL245570 | — | Ki | = | 38.4 | nM | 7.42 |
| CHEMBL441618 | — | Ki | = | 44.5 | nM | 7.35 |
| CHEMBL201525 | — | Ki | = | 56.5 | nM | 7.25 |
| CHEMBL245571 | — | Ki | = | 74.7 | nM | 7.13 |