Assay Detail
Binding
CHEMBL885890
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Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Dopamine/serotonin receptor ligands. Part 15: Oxygenation of the benz-indolo-azecine LE 300 leads to novel subnanomolar dopamine D1/D5 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.40 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL245764 | — | — | 1 | 9.64 |
| CHEMBL245570 | — | — | 1 | 9.41 |
| CHEMBL201170 | — | — | 1 | 8.82 |
| CHEMBL396560 | — | — | 1 | 8.44 |
| CHEMBL245571 | — | — | 1 | 8.27 |
| CHEMBL441618 | — | — | 1 | 8.12 |
| CHEMBL201525 | — | — | 1 | 7.95 |
| CHEMBL396561 | — | — | 1 | 7.50 |
| CHEMBL380330 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL245764 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL245570 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL201170 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL396560 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL245571 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL441618 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL201525 | — | Ki | = | 11.2 | nM | 7.95 |
| CHEMBL396561 | — | Ki | = | 31.5 | nM | 7.50 |
| CHEMBL380330 | — | Ki | = | 38.3 | nM | 7.42 |