Assay Detail
Binding
CHEMBL885899
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Inhibition of VEGFR1 by HTRF assay
74
Total Activities
74
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Vascular endothelial growth factor receptor 1 (CHEMBL1868) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
ortho-Substituted azoles as selective and dual inhibitors of VEGF receptors 1 and 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 74 | 6.15 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL202011 | — | — | 1 | 7.82 |
| CHEMBL24828 | VANDETANIB | 4.0 | 1 | 7.66 |
| CHEMBL153843 | — | — | 1 | 7.50 |
| CHEMBL101253 | VATALANIB | 3.0 | 1 | 7.27 |
| CHEMBL393779 | — | — | 1 | 7.06 |
| CHEMBL401041 | — | — | 1 | 6.89 |
| CHEMBL238522 | — | — | 1 | 6.75 |
| CHEMBL241265 | — | — | 1 | 6.68 |
| CHEMBL238737 | — | — | 1 | 6.68 |
| CHEMBL238529 | — | — | 1 | 6.68 |
| CHEMBL238526 | — | — | 1 | 6.64 |
| CHEMBL391127 | — | — | 1 | 6.60 |
| CHEMBL238521 | — | — | 1 | 6.60 |
| CHEMBL393924 | — | — | 1 | 6.55 |
| CHEMBL240455 | — | — | 1 | 6.55 |
| CHEMBL238719 | — | — | 1 | 6.55 |
| CHEMBL394020 | — | — | 1 | 6.54 |
| CHEMBL240643 | — | — | 1 | 6.54 |
| CHEMBL241314 | — | — | 1 | 6.48 |
| CHEMBL394204 | — | — | 1 | 6.47 |
| CHEMBL241084 | — | — | 1 | 6.46 |
| CHEMBL238528 | — | — | 1 | 6.43 |
| CHEMBL392513 | — | — | 1 | 6.43 |
| CHEMBL238720 | — | — | 1 | 6.36 |
| CHEMBL393963 | — | — | 1 | 6.25 |
| CHEMBL238530 | — | — | 1 | 6.24 |
| CHEMBL241667 | — | — | 1 | 6.19 |
| CHEMBL393418 | — | — | 1 | 6.19 |
| CHEMBL400216 | — | — | 1 | 6.18 |
| CHEMBL401040 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL202011 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL24828 | VANDETANIB | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL153843 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL101253 | VATALANIB | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL393779 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL401041 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL238522 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL241265 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL238737 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL238529 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL238526 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL391127 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL238521 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL240455 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL393924 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL238719 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL394020 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL240643 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL241314 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL394204 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL241084 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL238528 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL392513 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL238720 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL393963 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL238530 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL393418 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL241667 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL400216 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL401040 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL394203 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL238531 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL241669 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL392789 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL240209 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL240818 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL240406 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL238735 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL240607 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL429643 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL241313 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL392987 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL240608 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL241492 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL241466 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL241668 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL396144 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL240456 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL394436 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL429455 | — | IC50 | = | 2120.0 | nM | 5.67 |