Assay Detail
Binding
CHEMBL885944
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Inhibition of Trypanosoma brucei rhodesiense trypanothione reductase
34
Total Activities
31
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 4.97 | 5.40 |
| Ki | 3 | 5.48 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL247178 | — | — | 2 | 5.72 |
| CHEMBL246979 | — | — | 2 | 5.44 |
| CHEMBL247772 | — | — | 1 | 5.40 |
| CHEMBL1185172 | — | — | 1 | 5.30 |
| CHEMBL247379 | — | — | 1 | 5.30 |
| CHEMBL395209 | — | — | 2 | 5.27 |
| CHEMBL245550 | — | — | 1 | 5.16 |
| CHEMBL246381 | — | — | 1 | 5.16 |
| CHEMBL246579 | — | — | 1 | 5.10 |
| CHEMBL396068 | — | — | 1 | 5.10 |
| CHEMBL394283 | — | — | 1 | 5.05 |
| CHEMBL247576 | — | — | 1 | 5.05 |
| CHEMBL248185 | — | — | 1 | 5.00 |
| CHEMBL248184 | — | — | 1 | 4.80 |
| CHEMBL248381 | — | — | 1 | 4.72 |
| CHEMBL395210 | — | — | 1 | 4.62 |
| CHEMBL246164 | — | — | 1 | 4.60 |
| CHEMBL395161 | — | — | 1 | 4.54 |
| CHEMBL246163 | — | — | 1 | 4.46 |
| CHEMBL394098 | — | — | 1 | 4.23 |
| CHEMBL397851 | — | — | 1 | - |
| CHEMBL247575 | — | — | 1 | - |
| CHEMBL245353 | — | — | 1 | - |
| CHEMBL246379 | — | — | 1 | - |
| CHEMBL392851 | — | — | 1 | - |
| CHEMBL246380 | — | — | 1 | - |
| CHEMBL246580 | — | — | 1 | - |
| CHEMBL245352 | — | — | 1 | - |
| CHEMBL246353 | — | — | 1 | - |
| CHEMBL247577 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL247178 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL246979 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL247178 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL246979 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL247772 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1185172 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL247379 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL395209 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL245550 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL246381 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL246579 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL396068 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL247576 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL394283 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL395209 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL248185 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL248184 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL248381 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL395210 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL246164 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL395161 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL246163 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL394098 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL245353 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL246353 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL397851 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL246379 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL392851 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL246380 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL246580 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL246352 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL245352 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL247575 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL247577 | — | IC50 | > | 100000.0 | nM | - |