Assay Detail
Binding
CHEMBL885955
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Displacement of [3H]MPEP from mGlu5 receptor
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.88 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL245404 | — | — | 1 | 8.52 |
| CHEMBL66654 | — | — | 1 | 8.40 |
| CHEMBL415083 | — | — | 1 | 8.30 |
| CHEMBL245406 | — | — | 1 | 8.00 |
| CHEMBL394923 | — | — | 1 | 7.58 |
| CHEMBL245405 | — | — | 1 | 7.41 |
| CHEMBL239800 | FENOBAM ANHYDROUS | 2.0 | 1 | 7.21 |
| CHEMBL391604 | — | — | 1 | 7.11 |
| CHEMBL245606 | — | — | 1 | 6.78 |
| CHEMBL394922 | — | — | 1 | 6.54 |
| CHEMBL381820 | — | — | 1 | 6.50 |
| CHEMBL391401 | — | — | 1 | 6.23 |
| CHEMBL245607 | — | — | 1 | 6.18 |
| CHEMBL246235 | — | — | 1 | 6.16 |
| CHEMBL245403 | — | — | 1 | 5.95 |
| CHEMBL247495 | — | — | 1 | 5.87 |
| CHEMBL239799 | — | — | 1 | 5.60 |
| CHEMBL246234 | — | — | 1 | 5.57 |
| CHEMBL239802 | — | — | 1 | - |
| CHEMBL239801 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL245404 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL66654 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL415083 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL245406 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL394923 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL245405 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL239800 | FENOBAM ANHYDROUS | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL391604 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL245606 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL394922 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL381820 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL391401 | — | IC50 | = | 587.0 | nM | 6.23 |
| CHEMBL245607 | — | IC50 | = | 663.0 | nM | 6.18 |
| CHEMBL246235 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL245403 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL247495 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL239799 | — | IC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL246234 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL239802 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL239801 | — | IC50 | > | 5000.0 | nM | - |