Assay Detail
Binding
CHEMBL885975
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Inhibition of Escherichia coli H560 DNA gyrase assessed as DNA cleavage
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity relationships of 3-aminoquinazolinediones, a new class of bacterial type-2 topoisomerase (DNA gyrase and topo IV) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.50 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL247694 | — | — | 1 | 7.00 |
| CHEMBL383917 | — | — | 1 | 6.70 |
| CHEMBL393504 | — | — | 1 | 6.62 |
| CHEMBL245443 | — | — | 1 | 6.52 |
| CHEMBL397315 | — | — | 1 | 6.40 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 6.40 |
| CHEMBL393303 | — | — | 1 | 5.92 |
| CHEMBL247497 | — | — | 1 | 5.89 |
| CHEMBL247085 | — | — | 1 | 5.80 |
| CHEMBL248505 | — | — | 1 | 5.52 |
| CHEMBL247695 | — | — | 1 | 5.37 |
| CHEMBL247898 | — | — | 1 | 5.28 |
| CHEMBL393505 | — | — | 1 | 5.21 |
| CHEMBL248497 | — | — | 1 | 5.09 |
| CHEMBL245634 | — | — | 1 | 5.00 |
| CHEMBL394491 | — | — | 1 | 4.96 |
| CHEMBL248305 | — | — | 1 | 4.77 |
| CHEMBL437768 | — | — | 1 | 4.70 |
| CHEMBL248506 | — | — | 1 | 4.68 |
| CHEMBL247087 | — | — | 1 | 4.64 |
| CHEMBL395622 | — | — | 1 | 4.46 |
| CHEMBL247086 | — | — | 1 | 4.01 |
| CHEMBL245432 | — | — | 1 | - |
| CHEMBL247292 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL247694 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL383917 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL393504 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL245443 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL397315 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL393303 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL247497 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL247085 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL248505 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL247695 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL247898 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL393505 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL248497 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL245634 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL394491 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL248305 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL437768 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL248506 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL247087 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL395622 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL247086 | — | IC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL245432 | — | IC50 | - | — | - | |
| CHEMBL247292 | — | IC50 | > | 100000.0 | nM | - |