Assay Detail
Binding
CHEMBL886017
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effect on PPARgamma transactivation activity in HEK293 cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and evaluation of potent, structurally novel peroxisome proliferator-activated receptor (PPAR) delta-selective agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 5.69 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376165 | — | — | 1 | 6.19 |
| CHEMBL229573 | — | — | 1 | 6.00 |
| CHEMBL229525 | — | — | 1 | 6.00 |
| CHEMBL375471 | — | — | 1 | 5.96 |
| CHEMBL229778 | — | — | 1 | 5.89 |
| CHEMBL389903 | — | — | 1 | 5.89 |
| CHEMBL229836 | — | — | 1 | 5.85 |
| CHEMBL229837 | — | — | 1 | 5.82 |
| CHEMBL425666 | — | — | 1 | 5.75 |
| CHEMBL387914 | — | — | 1 | 5.66 |
| CHEMBL229831 | — | — | 1 | 5.64 |
| CHEMBL390116 | — | — | 1 | 5.62 |
| CHEMBL118939 | — | — | 1 | 5.58 |
| CHEMBL229786 | — | — | 1 | 5.44 |
| CHEMBL426371 | — | — | 1 | 5.21 |
| CHEMBL427071 | — | — | 1 | 5.16 |
| CHEMBL38943 | GW501516 | 2.0 | 1 | 5.07 |
| CHEMBL229785 | — | — | 1 | - |
| CHEMBL229888 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376165 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL229573 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL229525 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL375471 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL229778 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL389903 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL229836 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL229837 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL425666 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL387914 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL229831 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL390116 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL118939 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL229786 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL426371 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL427071 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL38943 | GW501516 | EC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL229785 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL229888 | — | EC50 | > | 10000.0 | nM | - |