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Assay Detail

CHEMBL886027

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Functional
Antiproliferative activity against human MCF7 cells after 5 days
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Antimitotic activities of 2-phenylindole-3-carbaldehydes in human breast cancer cells.
Kaufmann D, Pojarová M, Vogel S, Liebl R, Gastpar R, Gross D, Nishino T, Pfaller T, von Angerer E.
Bioorg Med Chem (2007) 15 : 5122 -5136
PubMed 17533132 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 34 7.03 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL374589 1 8.22
CHEMBL228524 1 7.70
CHEMBL228522 1 7.70
CHEMBL228681 1 7.68
CHEMBL228633 1 7.66
CHEMBL387754 1 7.66
CHEMBL376125 1 7.57
CHEMBL228578 1 7.43
CHEMBL148029 1 7.37
CHEMBL374801 1 7.27
CHEMBL390605 1 7.27
CHEMBL228580 1 7.24
CHEMBL228781 1 7.21
CHEMBL389046 1 7.19
CHEMBL374802 1 7.18
CHEMBL228632 1 7.17
CHEMBL228466 1 7.01
CHEMBL374590 1 7.00
CHEMBL228782 1 6.85
CHEMBL228682 1 6.85
CHEMBL145872 1 6.80
CHEMBL228579 1 6.78
CHEMBL228468 1 6.75
CHEMBL147487 1 6.75
CHEMBL228630 1 6.70
CHEMBL228631 1 6.70
CHEMBL228683 1 6.67
CHEMBL228680 1 6.66
CHEMBL228780 1 6.62
CHEMBL228523 1 6.41

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL374589 IC50 = 6.0 nM 8.22
CHEMBL228524 IC50 = 20.0 nM 7.70
CHEMBL228522 IC50 = 20.0 nM 7.70
CHEMBL228681 IC50 = 21.0 nM 7.68
CHEMBL228633 IC50 = 22.0 nM 7.66
CHEMBL387754 IC50 = 22.0 nM 7.66
CHEMBL376125 IC50 = 27.0 nM 7.57
CHEMBL228578 IC50 = 37.0 nM 7.43
CHEMBL148029 IC50 = 43.0 nM 7.37
CHEMBL374801 IC50 = 54.0 nM 7.27
CHEMBL390605 IC50 = 54.0 nM 7.27
CHEMBL228580 IC50 = 58.0 nM 7.24
CHEMBL228781 IC50 = 62.0 nM 7.21
CHEMBL389046 IC50 = 65.0 nM 7.19
CHEMBL374802 IC50 = 66.0 nM 7.18
CHEMBL228632 IC50 = 67.0 nM 7.17
CHEMBL228466 IC50 = 97.0 nM 7.01
CHEMBL374590 IC50 = 100.0 nM 7.00
CHEMBL228782 IC50 = 140.0 nM 6.85
CHEMBL228682 IC50 = 140.0 nM 6.85
CHEMBL145872 IC50 = 160.0 nM 6.80
CHEMBL228579 IC50 = 165.0 nM 6.78
CHEMBL228468 IC50 = 180.0 nM 6.75
CHEMBL147487 IC50 = 180.0 nM 6.75
CHEMBL228630 IC50 = 200.0 nM 6.70
CHEMBL228631 IC50 = 200.0 nM 6.70
CHEMBL228683 IC50 = 212.0 nM 6.67
CHEMBL228680 IC50 = 220.0 nM 6.66
CHEMBL228780 IC50 = 240.0 nM 6.62
CHEMBL228523 IC50 = 390.0 nM 6.41
CHEMBL228521 IC50 = 580.0 nM 6.24
CHEMBL376126 IC50 = 1660.0 nM 5.78
CHEMBL228577 IC50 = 1650.0 nM 5.78
CHEMBL90555 VINCRISTINE IC50 - -