Assay Detail
Binding
CHEMBL886077
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Inhibition of rabbit cathepsin K
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Beta-substituted cyclohexanecarboxamide cathepsin K inhibitors: modification of the 1,2-disubstituted aromatic core.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.89 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL245580 | — | — | 1 | 10.00 |
| CHEMBL201914 | — | — | 2 | 9.52 |
| CHEMBL395698 | — | — | 1 | 9.40 |
| CHEMBL391959 | — | — | 1 | 9.00 |
| CHEMBL247587 | — | — | 1 | 9.00 |
| CHEMBL245759 | — | — | 1 | 8.70 |
| CHEMBL395697 | — | — | 1 | 8.30 |
| CHEMBL247783 | — | — | 1 | 8.30 |
| CHEMBL245381 | — | — | 1 | 8.22 |
| CHEMBL245579 | — | — | 1 | 8.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL245580 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL201914 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL395698 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL201914 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL391959 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL247587 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL245759 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL395697 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL247783 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL245381 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL245579 | — | IC50 | = | 9.0 | nM | 8.05 |